Understanding immune health inside the uterus can be the missing piece in solving complex fertility issues. Here’s how Endometrial Immune Profiling helps—and how EMBRYOGENESIS is redefining fertility evaluation.
Introduction
Fertility is a complex journey, and sometimes, even when all routine parameters appear normal, conception remains a challenge. One often-overlooked factor is the immune environment of the uterus—a delicate balance that plays a key role in embryo implantation.
Endometrial Immune Profiling (EIP) is an advanced diagnostic test that helps assess the local immune activity of the endometrium (the inner lining of the uterus), particularly in women facing repeated IVF failures or recurrent pregnancy loss.
At EMBRYOGENESIS – Infertility Diagnostic & Research, we specialize in advanced fertility diagnostics like EIP, supporting couples with deeper evaluations when conventional tests fall short.
What Is Endometrial Immune Profiling?
Endometrial Immune Profiling is a specialized test that examines how your uterine immune cells and cytokines (signaling proteins) behave during the implantation window of your menstrual cycle.
The test identifies any immune dysregulation—either an overactive or underactive immune response—that might prevent a healthy embryo from implanting successfully.
It’s usually done during the luteal phase (7–10 days after ovulation), when the uterus should be in a receptive state. A small sample of the endometrial tissue is collected via biopsy and analyzed using molecular and immunohistochemical markers.
EIP helps reveal silent issues that conventional hormone or imaging tests may miss.
Why Does Endometrial Immunity Matter in Fertility?
The uterus isn’t just a passive site for embryo implantation. It’s an immune-active environment that must recognize and tolerate the embryo, while still protecting the body from potential threats.
If this immune balance is disrupted:
- An overactive immune response can attack the embryo, preventing implantation.
- An underactive immune response can fail to support proper endometrial receptivity.
Endometrial Immune Profiling provides crucial insights into this balance, allowing fertility specialists to tailor treatment plans that increase the chances of a successful pregnancy.
What Does the Test Involve?
At EMBRYOGENESIS, we perform EIP in a highly controlled and patient-friendly environment.
Here’s what to expect:
- Timing: The biopsy is done during the mid-luteal phase (usually Day 21 in a 28-day cycle).
- Procedure: A thin catheter is used to collect a small sample of endometrial tissue. It’s quick, outpatient-based, and generally well tolerated.
- Analysis: The sample is evaluated for immune markers like uNK cells, cytokines (e.g., IL-15, IL-18), and receptor expression.
Results are typically available within a week and interpreted by fertility immunology experts.
Who Should Consider Endometrial Immune Profiling?
EIP is not a routine test for all fertility patients. However, it is particularly recommended for:
Women with:
- 2 or more failed IVF attempts despite good-quality embryos
- Recurrent pregnancy loss (2 or more miscarriages)
- Unexplained infertility with no clear diagnosis from standard tests
- Autoimmune conditions like thyroiditis, lupus, or endometriosis
- A history of poor implantation response even with hormone support
How Does EIP Impact Fertility Treatment?
The primary value of EIP lies in personalizing treatment protocols. Based on the test results, doctors can:
- Modulate immune response with medications (e.g., steroids, IVIG, intralipids)
- Adjust the timing of embryo transfer based on endometrial receptivity
- Address chronic inflammation or microbial imbalance in the endometrium
- Recommend supportive treatments to promote tolerance of the embryo
In essence, EIP gives fertility specialists a more complete picture, which often leads to better outcomes in subsequent IVF cycles or natural conceptions.
Limitations to Keep in Mind
While Endometrial Immune Profiling is a powerful tool, it’s not a guaranteed solution. Some important considerations:
- The test is most useful when standard fertility treatments fail.
- Results need to be interpreted by experienced fertility specialists.
- It may not be available in all fertility centers.
That’s why it’s important to undergo EIP at a center like EMBRYOGENESIS, where the test is supported by integrated diagnostics, lab precision, and expert consultation.
Why Choose EMBRYOGENESIS for Advanced Fertility Evaluation?
At EMBRYOGENESIS – Infertility Diagnostic & Research, we go beyond standard fertility assessments. As part of our mission to “Redefine Fertility Evaluation,” we offer:
- Certified Endometrial Immune Profiling services
- State-of-the-art molecular labs
- Personalized treatment planning based on test outcomes
- A multi-disciplinary team of fertility experts, embryologists, and immunologists
Whether you’re a patient or a referring clinician, we ensure that each case receives the care and depth it deserves.
Conclusion
For individuals or couples who have faced multiple IVF failures or unexplained fertility struggles, Endometrial Immune Profiling can uncover hidden causes that routine tests may overlook.
By assessing the uterine immune environment, this test enables a more personalized, science-backed approach to fertility treatment.
If you’re considering advanced fertility diagnostics, reach out to our experts at EMBRYOGENESIS to learn how we can support your journey with clarity, care, and cutting-edge science.
Ready to explore Endometrial Immune Profiling?
Contact EMBRYOGENESIS today to schedule a consultation or learn more about the test.